Duvent 10mg Tablet 10pcs

Uses of Duvent 10mg Tablet

Allergic rhinitis, Chronic idiopathic urticaria.

How does Duvent 10mg Tablet work?

Acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors, and antagonizes platelet-activating factor (PAF).

Side Effects of Duvent 10mg Tablet

Headache, somnolence, fatigue/asthenia.

Quick Suggestions:

• Duvent 10mg Tablet is prescribed for allergy symptoms relief such as itching and swelling.
• It is less likely to cause drowsiness compared to similar medications.
• Be cautious while driving or engaging in activities requiring concentration, as it may cause dizziness.
• Avoid alcohol consumption during Duvent 10 treatment to prevent increased sleepiness.
• Stop taking Duvent 10 three days before undergoing an allergy test, as it can impact test results.

Indications:

Duvent 10mg Tablet is an effective anti-allergic medicine used to temporarily relieve the symptoms of seasonal allergies. 

Pharmacology

Rupatadine acts as a non-sedative antagonist at histamine H1-receptors, and it has an extended half-life. Additionally, it inhibits platelet-activating factor (PAF). Both histamine and PAF contribute to bronchoconstriction, and increased vascular permeability, and act as mediators in the inflammatory process. Rupatadine's dual mechanism of action provides a more effective therapeutic impact compared to a single antihistamine.

Moreover, Rupatadine inhibits mast cell degranulation triggered by both immunological and non-immune stimuli. It also suppresses the release of cytokines, particularly tumor necrosis factor-alpha (TNF), in human mastocytes and monocytes. These actions contribute to its efficacy in treating allergic conditions and inflammatory responses.

Dosage & Administration of Duvent 10mg Tablet

• Adult Dose: 10 mg (1 tablet) once daily.
• Child Dose: Children > 12 years: 10 mg (1 tablet) once daily. Not recommended for those below 12 years.

Interaction

When administered concurrently with ketoconazole or erythromycin, the systemic exposure of Rupatadine increases. Caution is advised when using Rupatadine with these medications and other CYP3A4 isozyme inhibitors. Additionally, caution is recommended when co-administering Rupatadine with statins, CNS depressants, or alcohol. Avoid consuming grapefruit or grapefruit juice simultaneously with Rupatadine.

Contraindications

Hypersensitivity, Avoid alcohol.

Pregnancy & Lactation

• There is no clinical data available regarding the use of Rupatadine during pregnancy.
• Pregnant women should avoid using Rupatadine unless the potential benefits outweigh the potential risks for the unborn child.
• There is no information on whether Rupatadine is excreted in breast milk.
• Therefore, the use of Rupatadine during lactation should be avoided unless the benefits to the mother justify the potential risk to the newborn child.

Precautions & Warnings

• Renal or hepatic insufficiency may impair the ability to drive or operate machinery. Pregnancy, lactation. Elderly, children <12 yr.

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.